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| Tiantan Puhua Stem Cell Centre, China | |||||||||||||
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| Stem Cell
Treatments offered at Tiantan Puhua Hospital, Beijing, China Stem Cell Treatment for Parkinson's hRPE adult stem cells are a new and most promising solution for Parkinson's Patients. hRPE cells can naturally provide a source of increased dopamine production to promote functional recovery in Parkinson's patients. Stem Cell Treatment for Traumatic Brain Injury Since most brain injuries affect several areas in the brain, the most effective and safe procedure to deliver the stem cells is via a spinal injection into the CSF (Cerebral Spinal Fluid), which circulates in and around the whole brain. Stem Cell Treatment for Cerebral Palsy The treatment includes stem cell implantation, a 'cocktail' of medications and brain nutrition materials given through IV, biofeedback treatment and comprehensive rehabilitation. At Tiantan Puhua hospital 3 main types of stem cells are being used: 1. Neural Stem Cells (derived from fetal stem cells) used for: Cerebral Palsy, Brain Injury, Stroke, Degenerative Diseases, and other neurological disorders. 2. hRPE Stem Cells (Adult Retinal Stem Cells) Used for: Parkinson's Disease 3. Bone Marrow Stem cells (Adult Bone Marrow stem cells extracted from the patient's own bone marrow) Recommended for young patients with a weak immune system. What are Neural Stem Cells? Neural Stem cells are self-regenerating, multipotent cells, found in the human brain which have the potential to differentiate into three major cell types: nerve cells (neurons), astrocytes and oligodendrocytes, and to self renew sufficiently to provide adequate number of cells in the brain. When brain cells are damaged or are dying, due to a disease or an injury, fetal stem cells are the best known source for human neural stem cells. Since most brain injuries, stroke, degenerative diseases and Demyelinating disorders affect several areas in the brain and not only one, the most effective and safe procedure to deliver neural stem cell into the brain is via a Lumbar Puncture (also called Spinal Tap): a spinal injection in the lumbar area (lower back) into the CSF (Cerebral Spinal Fluid). Lumbar Puncture method used at Tiantan Puhua Hospital, China During a lumbar puncture, a needle is carefully inserted into the spinal canal low in the back. A small amount of CSF is collected, then mixed with the stem cell fluid and injected back into the CSF. The CSF circulation (Cerebral Spinal Fluid) goes in and around the brain, separated from the blood circulation by the Blood Brain Barrier. One cycle of the CSF circulation takes between 6-7 hours. Within this time frame the stem cells will flow through the CSF into the brain. What are hRPE Stem Cells? hRPE (Human Retinal Pigment Epithelial) Stem Cells, are adult multipotent stem cells that are found in the retina of the human eye. The original function of these special cells is producing Dopamine that participates in the pigmentation process inside the retina. Due to their function, hRPE cells are a new and most promising solution for Parkinson's Patients who suffers from degeneration of their Dopamine-producing cells. Dopamine is a neuro-transmitter in our brain that supports our movement fluidity and continuity. hRPE cells can replace degenerated dopamine-producing neurons in the nigrostriatal pathway and provide a source of increased dopamine production to promote functional recovery in Parkinson's patients. The hRPE cells are derived from a single donor, then cultured in the laboratory to produce the amount and the type of cells fitting for implantation. The cells are then being injected within a single operation into 4 targets in the Putamen area in the brain, using MRI 3D image guided stereotactic technique. While the treatment can not completely remove all symptoms of the disease, it can greatly reduce the tremors, decrease muscle tension and rigidity, improve movement continuity, movement initiation and balance, increase muscle strength, improve slurred speech, reduce the freeze ups and strengthen the overall body. Every patient who wishes to apply for this treatment should undergo a thorough evaluation process. For more information please read Treatment for Parkinson's or contact us. What are Bone Marrow stem cells? Bone marrow stem cells are the most primal cells in the marrow. From them all the various types of blood cells are descended. Stem cells from bone marrow can also, under special conditions provided in the laboratory, give rise to non-marrow cells ? such as neural cells. Bone marrow cells, unlike other types of stem cells, are available to be extracted from the patient's own body. This availability carry very significant advantages for certain medical conditions: bone marrow cells, when extracted from the patient's own body, have no risk of stimulating the immune system. This advantage is crucial when the patient's immune system is weak. In medical conditions such as Multiple Sclerosis, certain brain infections, seizers and epileptic disorders or at any condition when the immune system is weak - bone marrow stem cell implantation will be recommended. The procedure of Bone Marrow culturing and implantation: On the first week upon the patient's arrival to the hospital, bone marrow is extracted from the patient's hip in a short and simple operation. This procedure is not painful and is done under a local anesthesia. The bone marrow cells are then sent to the lab and being cultures for about 3-4 weeks. In the lab, the cells are being induce into neural stem cells and then cultured to increase their number. The number of stem cells will be depending on the patient's age and the level of his bone marrow activity. Within a month from the bone marrow extraction, the cells will be injected back into the patients' body via lumbar puncture (spinal injection). (3-4 injections.) Sino Cells Bio Technologies Co., Ltd All stem cells used at Tiantan Puhua Hospital come from Sino Cells Bio Technologies Research Centre laboratories. Sino Cells Bio Technologies research center is the most renowned stem cell center in China, which holds a top level researchers team of international reputation. Self Stem Cells Activation and Proliferation: How do the stem cells survive, migrate and proliferate in the brain? Our stem cell program includes three main elements that are working together to initiate a regeneration process in the patient's brain and functional recovery: - Stem cell implantation - Daily IV of medicines (intravenous) - Physical and Occupational therapy Tiantan Puhua Hospital, Beijing, China holds the credit for a unique therapy of medicines, given through 6-8 weeks of daily IV. This formula, individually tailored for each patient's condition, aims at several targets: - To prepare and enhance the microenvironment in the patient's brain, to support and protect the implanted stem cells. - To cause migration of the stem cells to the relevant areas in the brain by creating chemical signalization. - To activate inactive neural stem cell in the patient's brain, allowing them activation, proliferation and then differentiation into mature functional brain cells. Adult stem cells can be found in different places in our body. Adult stem cells are also found in our brain, residing within the periventricular subependymal zone and hippocampus. These cells are multipotent and can give rise to all three types of cells of the central nervous system. However, these stem cells are not active and are used as reserve cells. They exist in our brain as if 'sleeping', waiting for a signal that will 'wake' them into action. With a certain combination of medicines these stem cells can be 'awaken' and start to proliferate, differentiate and produce more brain cells. 'Wakening up' these 'sleeping' neural stem cell is the main goal of the daily IV you will be receiving daily thorough the whole treatment period. Through several years of applying this cell therapy for a wide range of neurological disorders, this non-invasive and safe treatment has proved itself to be a highly effective for both moderate level and severe level of neurological disorders. Rehabilitation Center at Tiantan Puhua Stem Cell Centre, China Physiotherapy is an integral part of stem cell therapy. The physical therapy stimulates the new cells in their process of becoming functional cells and has an important role in helping the cell migrating into the injured areas. Our treatment program includes daily sessions of physical and occupational therapy, and as a complementary treatment sessions of professional traditional Chinese medicine such as acupuncture and Chinese manipulation massage. Our rehabilitation center is placed in a short walking distance from the patients' room for an easy access. Our physiotherapists are all professionally trained and are committed to support patients through the hard work of rehabilitation and educate patients toward better mobility, functionality and recovery. For Detailed Dossier on Tiantan Puhua Stem Cell Centre, Beijing, China please write to us at mktg@mediescapes.com |
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